VPRIV (velaglucerase alfa) is a medication used for long-term enzyme replacement therapy in patients 4 years of age and older with type 1 Gaucher disease.
Type 1 Gaucher disease is a rare, inherited genetic disorder, which results in a deficiency of an enzyme called glucocerebrosidase. This enzyme is responsible for breaking down a fatty substance in the body, referred to as glucocerebroside. When this enzyme doesn’t function effectively, glucocerebroside accumulates in cells throughout the body. These enlarged cells accumulate in the organs, most notably in the spleen and the liver, and in various tissues. This can also lead to low red blood cell and low platelet counts.
VPRIV is an intravenous infusion administered over 1 hour every other week.
Potential Side Effects
The most common side effects of VPRIV include hypersensitivity reactions, headache, dizziness, abdominal pain, nausea, back pain, joint pain, prolonged activated PTT, fatigue/asthenia (weakness), and/or pyrexia (fever).
VPRIV can cause serious side effects including hypersensitivity reactions such as anaphylaxis. You will be monitored during your infusion and may require observation following your infusion for signs and symptoms of a reaction which may include: rash, itching, hives, fatigue, coughing, wheezing, difficulty breathing, shortness of breath, throat irritation or pain, swelling of the throat, nausea, vomiting, headache, dizziness, fever, increased heart rate, and/or redness on your face (flushing).
For a full list of potential side effects, please see the Important Safety Information and Medication Guide on the VPRIV website.
Before you attend your first appointment at Sage Infusion, please make sure to review the documents below. The Patient Consent Form and HIPAA Privacy Authorization Form need to be filled out and signed ahead of your appointment, whereas the Notice of Privacy Practices and Patient Rights and Responsibilities are for reference only. Please contact us if you have any questions!
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